中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (52): 9752-9755.doi: 10.3969/j.issn.1673-8225.2010. 52.016

• 骨与关节图像与影像 bone and joint imaging • 上一篇    下一篇

低浓度低剂量碘对比剂多层螺旋CT犬颈部动脉的三维成像

翟凤馨，牛玉军，王志铭，雷  振   

  1. 辽宁医学院附属第一医院放射科，辽宁省锦州市121001
  • 出版日期:2010-12-24 发布日期:2010-12-24
  • 通讯作者: 王志铭，辽宁医学院附属第一医院放射科，辽宁省锦州市121001
  • 作者简介:翟凤馨，女，1963年生，辽宁省兴城市人，汉族，承德医学院毕业，主管护师，主要从事临床护理专业工作。 zaifx091229@126.com
  • 基金资助:

    辽宁省自然科学技术基金(20092187)，课题名称：低浓度低剂量碘对比剂降低肾脏损害的实验研究。

Three-dimensional imaging of multi-slice spiral CT angiography with low concentration and low dose iodine contrast agent in canine carotid artery 

Zhai Feng-xin, Niu Yu-jun, Wang Zhi-ming, Lei Zhen   

  1. Department of Radiology, First Affiliated Hospital of Liaoning Medical University, Jinzhou   121001, Liaoning Province, China
  • Online:2010-12-24 Published:2010-12-24
  • Contact: Wang Zhi-ming, Department of Radiology, First Affiliated Hospital of Liaoning Medical University, Jinzhou 121001, Liaoning Province, China
  • About author:Zhai Feng-xin, Nurse-in-charge, Department of Radiology, First Affiliated Hospital of Liaoning Medical University, Jinzhou 121001, Liaoning Province, China zaifx091229@126.com
  • Supported by:

    Natural Science and Technology Foundation of Liaoning Province, China, No. 20092187﹡

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摘要：

背景：随着碘对比剂在CT增强检查中的大量应用，其不良反应亦受到广泛关注。在不影响图像诊断质量的前提下，使用低浓度低剂量碘对比剂降低人体毒副反应具有重要的研究价值。
目的：验证低浓度低剂量碘对比剂在犬颈部动脉成像中的可行性。
方法：将3种不同浓度碘对比剂(370，350，300 mgI/mL)分别分成高、中、低剂量组(1.50，1.25，1.00 mL/kg)，共9个实验组。对3只家犬进行多层螺旋CT颈部动脉成像重复扫描，每组扫描8次。原始数据进行三维成像，包括容积重现、多平面重建；二维成像包括最大密度投影和曲面重建。由两名放射科医师对血管边缘及血管分支显影情况进行评分。
结果与结论：各实验组多层螺旋CT犬颈部动脉CT血管成像血管边缘及分值情况评分结果显示，血管边缘显示良好(评分>2分)，血管分支显示良好(评分>3分)。犬颈部动脉边缘显影情况及分支显影情况的评分结果具有较强的一致性，其Kappa值分别为0.799，0.733。9个实验组间动脉边缘及分支显影两两比较差异均无显著性意义(P > 0.05)。提示应用低浓度低剂量碘对比剂可获得良好的多层螺旋CT犬颈部动脉CT血管成像图像。

关键词: 碘对比剂, 颈动脉, CT血管成像, 动物实验, 低浓度, 低剂量

Abstract:

BACKGROUND: With a large number of applications of iodine contrast agent in enhanced CT examination, the adverse reaction has also been attracted a widespread attention. Under the premise of without affecting the diagnostic quality of CT images, the use of low concentration and low dose iodine contrast agent reducing the toxic reactions of the body have important research value.
OBJECTIVE: To verify the feasibility of low concentration and low dose iodine contrast agent in carotid artery imaging of canine.
METHODS: Three different concentrations of iodine contrast medium (370 mgI/mL, 350 mgI/mL, 300 mgI/mL) were divided into 9 experimental groups (high dose, medium dose, and low dose groups). Three canis familiaris were received multi-slice spiral CT angiography carotid artery imaging repeated sweep, 8 times scanning for each group. The original data were undergoing three-dimensional reconstruction, including volume reconstruction and multi-planar reconstruction; two-dimensional imaging, including maximum intensity projection and surface reconstruction. Vascular edge and development of vascular branches were scored by two radiologists.
RESULTS AND CONCLUSION: The score results showed that the vascular edge (score > 2 points) and the development of vascular branches (score > 3 points) display good in canine carotid artery imaging. The edge of canine carotid artery imaging and the branch carotid artery imaging have strong consistency, the Kappa values were 0.799, 0.733, respectively. There was no significant difference between the edge of artery and branch artery imaging of pairwise comparison in 9 experimental groups (P > 0.05). It is indicated that the application of low concentration and low dose iodine contrast agent can obtain good multi-slice spiral CT canine carotid artery CTA angiography image.

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